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Utilizing Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), we performed post-translational modification analysis on NHR-49::GFP immunoprecipitations 42 under fed and fasted states and identified a single phosphorylation event with high confidence within the receptors hinge region at serine 114 (Fig

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Notably, PPAR alone is not sufficient to restore redox homeostasis and promote the M2 phenotype, as demonstrated by the exacerbation of neuroinflammatory cytokine production in NRF2-deficient mice challenged with LPS (Innamorato et al., 2008)