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GLP-1 (glucagon-like-peptide-1), a receptor agonist This means that it mimics the hormone GLP-1, which regulates hunger and food intake

Potential therapies include gene intervention, probiotic therapy, fecal microbiota transplantation, TMAO and tryptophan metabolism regulation, SCFA therapy and pharmacological or nutritional therapies

Retatrutide data on this point is still being collected through the TRIUMPH maintenance arms

Research shows that GLP-1 receptor agonists work by slowing stomach emptying and signaling fullness to the brain, so discontinuing them suddenly removes those biological brakes almost immediately