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The D-Retro-Inverso modification uses D-amino acids in reverse sequence, ensuring resistance to proteolytic degradation while preserving the capacity to interfere with the target protein interactions

According to Mankin et al, the rigorousness of the OA destruction was categorized using the histologic standards (Table 2) based on structural variations (scale range 06), cellular variations (scale range 03), damage of safranin O staining (scale range 04) and tidemark integrity (scale range 01) by 3 independent researchers

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