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Melatonin effectively alleviates nociplastic pain and associated behavioral disturbances by modulating glutamatergic-related synaptic markers in the DRG, restoring mitochondrial function, and reducing microglial activation in the spinal cord

Although CPT1A and CPT1B exhibit considerable sequence similarity, the sensitivity of these two enzymes to their physiological inhibitor, malonyl-CoA, differs greatly (CPT1A has a ten-fold higher Ki for malonyl-CoA) 39,40

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30, 2024, pp