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GIP receptor activation plays a different but equally important role by: Improving insulin sensitivity at the cellular level , allowing cells to respond more effectively to insulin Enhancing fat metabolism and reducing signals that promote fat storage Reducing post-meal glucose spikes by improving glucose disposal This second pathway directly addresses one of the core drivers of insulin resistance: poor cellular response to insulin despite high circulating levels

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LG: Conceptualization, Project administration, Supervision, Visualization, Writing review & editing

10.1371/journal.pone.0053250 330 WidnerB.LeblhuberF.FuchsD