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Research has also generally suggested tirzepatide achieves better results, as it mimics the effects of GLP-1s and another hormone known as GIPs

This common question arises among patients starting glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound)

Luo Y, Yang S, Zeng H, Liu S, Zhang Y, Li JE, Liu J (2025) Both subcutaneous semaglutide and calorie restriction improves pancreatic cell hyperplasia and gut microbiota in high-fat diet-induced obese mice

Synovial inflammation is associated with pain sensitization in patients with knee OA 46 , suggesting a role of pro-inflammatory mediators in this process 39