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Pharmacologically, signaling studies demonstrate that tirzepatide mimics the actions of native GIP at the GIP receptor but shows bias at the GLP-1 receptor to favor cAMP generation over -arrestin recruitment, coincident with a weaker ability to drive GLP-1 receptor internalization compared with GLP-1

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Case 2 does not follow any of the two endotypes but responded to the treatment in the same time frame

Significant Weight Loss: On average, participants achieved 11 lbs of weight loss in 12 weeks , with some individuals experiencing up to 25 lbs of weight loss within the same period