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Discussion Colistin is a cyclic heptapeptide with an acylated tripeptide side chain that exerts its antimicrobial activity by disrupting the integrity of the bacterial membrane and increasing its permeability, leading to leakage of the cell content, membrane depolarization and cell death 1

Image Credit: azimmytws / Shutterstock.com A recent BMJ study determines whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists by type 2 diabetes (T2D) patients increases the risk of self-harm, suicidal ideation, and suicide as compared to patients prescribed dipeptidyl peptidase-4 (DPP-4) or sodium-glucose cotransporter-2 (SGLT-2) inhibitors

Pancreatic lipid accumulation can lead to dysregulation of -cell insulin secretion, and ultimately to apoptotic cell death

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