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Further mechanistic studies showed that NNMTi increases intracellular NAD levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies

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Selenium was found to play a role in thyroid function and it is postulated that the link is through a specific enzyme called type-1 5-deiodinase, which is involved in the conversion of thyroid hormones, which contains selenium [23]

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