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The longer-term benefits and harms of glucagon-like peptide-1 receptor agonists: a systematic review and meta-analysis

This sounds revolutionary, but it has received a mixed reception among clinicians, with many citing concerns that once-monthly dosing may paradoxically worsen patient compliance (patients may simply forget to take the medication, as once-monthly administration may not be frequent enough to build adherence behaviours) and slow dose titration

Besides helping people to control their diabetes and to lose substantial amounts of fat, these compounds appear to offer many additional health benefits

More recently, Choi and colleagues evaluated the cost-effectiveness of SGLT2is and GLP-1RAs, taken individually, as first-line therapies for American patients with T2DM, compared with metformin as first-line therapy