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So, if your vitamin B12 is not working properly because your folate metabolism isnt working properly this causes homocysteine imbalances which are considered a serious health problem for anyone especially for those with MTHFR gene mutations. 4 Reactions to Methylfolate supplementation Individuals that cannot tolerate Methylfolate often have low B12 levels in their cells

Conversely, oral supplements may take longer to produce noticeable effects, as they need to be digested and absorbed into the bloodstream

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