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If you have any sort of GI issue (GERD, reflux, SIBO/SIFO, yeast problems, chronic constipation, etc.) you will have problems taking oral forms of vitamin B12

Digestion and Absorption of Unbound B12 In supplements, B12 is not bound to protein, and therefore does not need digestive enzymes or stomach acid to be detached from a protein

Vitamin B12 deficiencies can be caused by many factors, such as older age, gastrointestinal conditions, and vegan or vegetarian diets

Fibroblast proliferation and collagen synthesis Fibroblasts are the cells responsible for producing the extracellular matrix, the structural scaffold that holds tissues together