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The mean changes from baseline to Week 26 were -2.2 kg, -3.1 kg and -0.6 kg in the semaglutide tablets 7 mg, semaglutide tablets 14 mg and sitagliptin 100 mg arms, respectively

Most patients notice the first symptomsmild nausea, slight appetite suppression, or stomach discomfortwithin 24 to 48 hours

In patients with diabetes, pharmacologic adjuvants, such as metformin, that improve glycemic control and reduce insulin resistance are also beneficial (7)

Avoid stimulant-based energy supplements that can worsen dehydration and anxiety