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During the 68-week treatment periods in Studies 2 and 3 [see Clinical Studies (14.2)], 50/1709 (3%) of WEGOVY-treated patients developed anti-semaglutide antibodies

Human and Animal Rights and Informed Consent This article does not contain any studies with animal subjects performed by any of the authors

The VEGFR2-independent mechanism involves Src kinase-mediated phosphorylation of caveolin-1, disrupting the inhibitory interaction between caveolin-1 and eNOS

Implications for neurodegenerative diseases The potential for GLP-1R agonism to protect the brain and improve cognitive function has spurred interest in its use as a therapeutic strategy for neurodegenerative diseases like Alzheimer's