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Within the mitochondria, lactate can be oxidized to pyruvate by a complex referred to as the mitochondrial lactate oxidation complex, mLOC

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Survodutide features an optimized N-terminal structure conferring resistance to dipeptidyl peptidase-4 (DPP-4) degradation and incorporates a C18 diacid-albumin binding moiety attached via a glycine-serine linker to substantially prolong its half-life, enabling once-weekly subcutaneous administration [143]