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Pools of Placebo-Controlled Clinical Trials for Glycemic Control in Adults Pool of 8 Placebo-Controlled Adult Trials for Dapagliflozin and Metformin HCl for Glycemic Control Data from a prespecified pool of adult patients from 8 short-term, placebo-controlled trials of dapagliflozin coadministered with metformin HCl immediate- or extended-release was used to evaluate safety

Yield Optimization: By reducing coupling steps (from 39 to 12), total yield increases from 15% to 42%

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Limit Snacking : Extending time between meals can allow insulin and GLP-1 levels to reset