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IGF-1 LR3 Clinical Evidence Context Direct human evidence on IGF-1 LR3 There are no published human clinical trials of IGF-1 LR3 itself

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In this pathology, IGF-I levels diverge between studies, from increased to decreased IGF-I concentrations[330332], probably due to differences in samples origin (serum/cerebrospinal fluid vs spinal cord/musculoskeletal) and could be explained as a physiological defensive mechanism promoted in response to the neural degeneration and/or muscle atrophy