Hepatology 2012;56:73546 [DOI] [PubMed] [Google Scholar] 52.Du YC, Lai L, Zhang H, Zhong FR, Cheng HL, Qian BL, Tan P, Xia XM, Fu WG.Kaempferol from penthorum chinense pursh suppresses HMGB1/TLR4/NF-kappaB signaling and NLRP3 inflammasome activation in acetaminophen-induced hepatotoxicity
Activation of TOX then initiates a series of cascading responses, including the activation of transcription factors such as TCF7 (encoding TCF-1) and Nr4a2, promoting the expression of inhibitory receptors such as PD-1, LAG-3, and HAVCR2, and accelerating the process of T cell exhaustion [66]
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