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Front Immunol (2023) 14:1091541

A 2016 systematic review of clinical evidence on newer vs older diabetes medications supports metformin as 1st-line therapy for type 2 diabetes given its relative safety & beneficial effect to lower HbA1c, absence of weight gain, and reduced cardiovascular mortality (Maruthur et al, 2016)

clinical studies have shown that using GHK-Cu can lead to measurable improvements

Glutathione when used as a supplement for skin whitening has been shown to be safe and effective in numerous clinical studies, and according to a double-blind placebo-controlled clinical trial by National Institute of Health [1], Glutathione treatment has been proven to significantly lower the skin melanin index of study participants after a few weeks of use