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Treatment may have come too late One possibility is that GLP-1 RAs are being administered too late in the disease course to meaningfully alter its trajectory
Metformin and sitagliptin daily doses were increased (2000 mg and 100 mg, respectively) and glimepiride 4 mg/day and pioglitazone 15 mg/day were added, although the latter was suspended two months after its initiation because of significant peripheral edema
We point out this decline is likely more moderate than concerns and stock reactions imply, they said
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