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Participants with normal hepatic function were eligible for inclusion if they were judged to be of general good health by the investigator, based on a medical examination (including physical examination, medical history, vital signs and ECG) and had liver enzyme levels within prespecified limits (alanine aminotransferase upper limit of normal [ULN] + 10%, aspartate aminotransferase ULN + 20% and total bilirubin ULN + 20%)

B-vitamins are a group of 8 different vitamins: Thiamine (vitamin B1) Riboflavin (vitamin B2) Niacin (vitamin B3) Pantothenic acid (vitamin B5) Pyridoxine (Vitamin B6) Biotin (vitamin B7) Folate (vitamin B9) Cobalamin (vitamin B12) B-vitamins are well known for their role in energy production

Elimination of VPA follows first-order kinetics, with a half-life ranging from 5 to 20 hours (mean 11 hours)

Trader sentiment reflects uncertainty around whether formal Category 1 placement occurs before or after that meeting, given the distinction between removal from Category 2 and affirmative listing, as well as ongoing questions about manufacturing standards and clinical evidence thresholds