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Circadian rhythm disruption is both a symptom and a driver of depression

Cyanocobalamin is indicated for vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug Interactions), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue

At sub-maximal doses, the combination produced greater weight loss than either compound alone

In addition, as we age, our ability to absorb B12 from food declines, which puts the elderly at higher risk of deficiency