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Neurodegenerative diseases Similar to muscle diseases, neurodegenerative conditions present altered mitochondrial homeostasis and NAD + metabolism, which have been thoroughly investigated as targets for NAD + modulation-based approaches 13,268,269

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After common infections, autoimmune conditions and other hemalotogical conditions had been excluded, a provisional diagnosis of vitamin B12 deficiency induced pyrexia, hemolytic anemia and thrombocytopenia was postulated and treatment was started with treatment of injection cyanocobalamin 1000 mcg OD supplemented, vitamin D 60,000 IU/week and calcium

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