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Similarly, in Kctd13 (a gene within 16p11.2 CNV) haploinsufficient and knockout mice, there was an increase in RhoA expression coupled with deficiencies in synaptic signalingan effect that was ameliorated with Rhosin treatment [137]

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Michael Freemark reports that he is an investigator on a study of the treatment of monogenic obesity sponsored by Rhythm Inc

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