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The use of their NOX-inhibitory properties in vivo may thus be problematic (Cipriano et al., 2023)

The best studied uses are for Parkinsons disease and side effect reduction associated with conventional cancer treatments

In this situation, it can be challenging to demonstrate B12 deficiency even when there are typical symptoms (including neuropathy-like paraesthesia and numbness), as serum B12 concentrations may be just within, or sometimes above, the normal range due to the oral supplementation

Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: A Mendelian randomisation analysis