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However, acetaminophen inhibits both COX isoforms by acting on the peroxide site and reducing the amount of the PTGS oxidized form required for AA conversion [2,80,81]

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Those SNPs, polymorphisms that are not located near any known genes, map to a region that displays significant evolutionary conservation and that may contain transcription factor binding sites or encode transcripts that are involved in the trans -regulation of the transcription of distant genes or the regulation of not yet identified genes