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Description

The pathogenesis of RIP involves multiple pathological processes, including radiation-induced excessive production of reactive oxygen species (ROS), leading to oxidative stress, which in turn triggers apoptosis and mucosal barrier disruption, as well as an inflammatory cascade centered on proinflammatory cytokines

For example, a lysosome-targeting chimera was created to engulf membrane protein 65

doi: 10.1016/j.freeradbiomed.2023.05.019 269 ChandrasekaranPRMadanagopalanVG