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Also, vomiting (if it occurs) can directly cause loss of nutrients and fluids

Still, major trials on two GLP-1 drugs (tirzepatide and semaglutide) offer some information about the impact of these medications on muscle loss, according to a 2025 analysis in Obesity Reviews

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Although manufacturer savings cards and patient assistance programs may reduce costs for some commercially insured patients, these programs often exclude Medicare and Medicaid beneficiaries and frequently contain annual savings caps or eligibility limitations