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Hypoxic stress forces irreversible differentiation of a majority of mouse trophoblast stem cells despite FGF41

In agreement with our findings, recent genomic gene expression profiles by microarray analyses in a gene dose-response model of Nrf2-null model have revealed that graded activation of Nrf2 increased the transcription of a large number of genes involved in Nrf2-mediated oxidative stress response, glutathione metabolism, and xenobiotic metabolism, including several genes responsible for the reduction of superoxide ions using GSH, i.e., glutathione peroxidases Gpx2 and Gpx4 , which augmented by 2260 and 105%, respectively, in Keap1-HKO mice compared to WT mice (Wu et al., 2011)

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Additionally, this combination can cause skin irritation and dryness, especially for sensitive skin