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Fourthly, GLP-1 protects cardiomyocytes from oxidative stress and apoptosis in diabetes mellitus, through the mTOR complex1/p70 ribosomal protein S6 kinase (p70S6K) pathway [160]

The dose dependent relationship of SGLT2i and incidence of DKA remains unclear and further investigation is warranted

Lasting Remodeling: Gene expression changes produce sustained collagen rebuilding that develops over weeks to months rather than delivering only transient effects

Lifestyle modifications : Patients who successfully implement and maintain dietary changes, physical activity routines, and behavioral strategies during treatment tend to experience less dramatic weight regain, though some regain typically still occurs