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However, in addition to the advanced instrumentation and analytical techniques, the quality and behavior of the biological samples remain crucial for successful structure determination using both methods, with flexibility and conformational dynamics being the usual reasons for decreasing resolution

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In vitro and in vivo drug metabolism analysis of BPI-460372 - A covalent TEAD1/3/4 inhibitor

Half-life of a drug is affected by several factors, including the drugs metabolism, its route of administration, and its affinity for certain tissues