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Additionally, there was a notable reduction in ET-1 secretion into the media after 24 h (Woodcock et al., 2013)

Losartan administration caused an improvement in serum TAS, GSH, TOS, GSSG, and MDA levels depending on the dose

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While Ex4 mildly reduced morphine-induced hyperlocomotion, it did not attenuate the expression of morphine-induced CPP, indicating a lack of effect on opioid reward in this model