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Luteolin is derived from a wide range of sources and present in various herbs

Under conditions of chronic stress or systemic inflammation, enzymes such as indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are upregulated, diverting TRP metabolism away from 5-HT synthesis toward KYN production, with profound consequences for both peripheral physiology and central nervous system (CNS) function

Other Ingredients: Gelatin (capsule), magnesium silicate, silicon dioxide, stearic acid

Both approaches have evidence supporting them this RCT provides the strongest clinical evidence, while the 2021 Pamela R.D