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During neurodegenerative disorder glial cells release some factors to reestablish integrity and repair damaged cells

Co-treatment with NAC significantly reversed epalrestat-induced upregulation of 4-HNE level and potentiated the anti-arthritic effect of epalrestat, suggesting that the combined therapy of epalrestat with NAC may sever as a potential approach in treating RA

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(1984), and Chambers et al