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Hypoglycaemia risk and mechanisms: Ozempic's glucose-dependent mechanism of action means that hypoglycaemia risk is relatively low when used as monotherapy

Co-chaired by Alex Azar, former HHS Secretary, and Megan Ranney, Dean of the Yale School of Public Health, the series creates space for nuanced discussion and respectful debate among a diverse set of experts

Tirzepatide, which acts on both GIP and GLP-1 receptors, appears to have a somewhat more favorable GI tolerability profile, possibly because GIP receptor activation partially counteracts the nausea-inducing effects of GLP-1 agonism