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Lancet 386, 7484 (2015)

In the peripheral nervous system, GLP-1Rs are expressed on vagal afferent neurons, enteric neurons, dorsal root ganglia, and nerves innervating metabolically active tissues such as adipose tissue and the gastrointestinal tract

This continuous bile flow actually makes the digestive system less efficient at breaking down larger fat meals, sometimes leading to post-cholecystectomy syndromea collection of ongoing digestive symptoms affecting 1015% of patients