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Description

The metabolites 3-oxoLCA and isoLCA were shown to inhibit T H 17 cell differentiation by binding to transcription factor retinoid-related orphan receptor (ROR) t (172, 173), while production of mitochondrial reactive oxygen species by isoalloLCA increased expression of FoxP3 and Treg cell differentiation (172) (Figure 1)

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Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer

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