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doi: 10.1111/dom.15802

Liraglutide treatment ameliorates IL-1-induced ROS production in cardiomyocytes, protects against IL-1-induced loss of mitochondrial membrane potential and decreased ATP generation, and counteracts IL-1-induced alterations in AMPK and acetyl-CoA carboxylase phosphorylation as well as the reduction of peroxisome proliferator-activated receptor coactivator-1 (PGC-1), which is a key regulator whose downregulation leads to cardiac mitochondrial dysfunction (168)

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7 Conclusion and challenges GLP-1RAs have been used to treat T2DM since 2005 and gained approval for weight management in 2014