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In sensitive individuals, sustained elevation may cause gynecomastia or reproductive effects These hormonal effects are generally not observed at doses of 100 mcg or below Theoretical/Long-Term: Potential effects on glucose metabolism and insulin sensitivity with prolonged use As with all GH-elevating compounds, theoretical concern regarding promotion of growth in undiagnosed malignancies Water retention and tingling typically diminish within the first few weeks as the body adapts

If late-stage results continue to support strong weight reduction and acceptable tolerability, retatrutide could become one of the most important next-generation obesity drugs globally