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10.1074/jbc.271.34.20631 J

Hence, we would like to emphasize that GLP-1 has not only an indirect incretin effect which improves key parameters associated with NAFLD, but it also shows a direct insulin-like role, repressing regulatory genes associated with obesity, NASH and hepatic triglyceride accumulation

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Ethics declarations Competing interests All authors are employees of Heptares Therapeutics Ltd and are shareholders in Sosei Group Corporation