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Amphetamines induced the activation of the endoplasmic reticulum (ER) stress signaling pathway in hippocampal neurons, accompanied by the destruction of ER function and the change of calcium homeostasis 31,32
doi: 10.1074/jbc.M805287200 89 ChenKKirberMTXiaoHYangYKeaneyJFJr.Regulation of ROS signal transduction by NADPH oxidase 4 localization
This in turn leads to the induction of AP-1-dependent target genes, involved in cell proliferation, DNA repair, and cell death 27
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