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Host factors in addition to the above, factors that may enhance the risk of liver disease include: Large body mass index/obesity Diabetes mellitus Renal failure Drugs That May Damage the Liver Antibiotics Anticonvulsants Antidepressants Antifungal drugs Antihypertensive drugs (for high blood pressure, kidney, or heart disorders) Antipsychotic drugs Antiretroviral therapy ART Heart drugs Hormones and related drugs Pain relievers Other drugs Medicinal herbs Liver disease and liver disorder can quickly change from nagging pain to quite dangerous