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Dietary tablet supplements of vitamin B12 and fortified foods are usually in the form of cyanocobalamin because it is a more cost-effective form of B12

Capella-Gutirrez S, Silla-Martnez JM, Gabaldn T

In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )