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Significant weight fluctuations (whether gain or loss) appear to increase risk more than steady, gradual change

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The existence of this transporter has been postulated (Mugford et al., 2009, 2010) based on following observations: (i) There are two parallel plastidic and cytoplasm-localized pathways for the production of PAPS in the cell and both PAPS pathways are capable of providing essential PAPS for the growth and development of plants