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In nutrient-rich conditions, mTOR remains active, suppressing autophagy initiation, while under stress conditions such as energy deficiency or DNA damage, the activation of AMP-activated protein kinase (AMPK), p53 or inhibition of pathways like PI3K/Akt and ERK reduces mTOR activity, which then releases the inhibition on autophagy and facilitates its initiation (Yang and Klionsky, 2010)

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| Weeks | Dose | Purpose | |---|---|---| | 1 to 4 | 0.25 mg once weekly | Tolerability induction | | 5 to 8 | 0.5 mg once weekly | Minimum effective therapeutic dose | | 9 to 12 (optional) | 1.0 mg once weekly | Enhanced glycemic control | | 13 to 16 (optional) | 1.7 mg once weekly | Bridge to maximum dose | | 17+ (optional) | 2.0 mg once weekly | Maximum approved dose for T2D | Dose advancement is not mandatory at every step

Services and treatments not offered in every state, include medical treatment of overweight and obesity including lifestyle counseling (e.g., diet and exercise) and prescription medications, if clinically appropriate, based on completion of required consultation