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CNS Drug Rev 7:283304 Simon N, McNamara K, Chow C, Maser R, Papakostas G, Pollack M, Nierenberg A, Fava M, Wong K (2008) A detailed examination of cytokine abnormalities in major depressive disorder

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In adults with obesity and knee osteoarthritis, retatrutide delivered: 9mg dose: 26.4% body weight reduction at 68 weeks 12mg dose: 28.7% body weight reduction at 68 weeks (average of 71.2 pounds lost) Placebo: 2.1% body weight reduction The 68-week timeframe is longer than the Phase 2 trial, which partially explains the higher numbers