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And its a history with its share of ignominy: In the mid-1990s, a drug that combined fenfluramine and phentermine, known as fen-phen, exploded in popularity after a single, 121-patient study showed it was effective for weight loss

It is not a licensed medicine, is not approved for human or veterinary use, and must not be administered to any living organism outside a formally approved research protocol

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The first of these drugs, cimetidine, was developed by James Black (figure 27), a Scottish physician and pharmacologist with a long-standing interest in the gut and the challenge of treating gastric and duodenal ulcers