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Clinical trial data from the SURMOUNT series shows these incidence rates: Nausea: approximately 20 percent of patients Diarrhea: approximately 16 percent of patients Vomiting: approximately 9 percent of patients Constipation: varies by dose level Decreased appetite: expected therapeutic effect Abdominal pain: less common but reported Most gastrointestinal side effects are mild to moderate and occur during the first few weeks of treatment or after dose increases

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These may be appropriate for patients at higher nutritional risk or those recovering from illness

Recent advances in the modulation of pain by the metabotropic glutamate receptors