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The ROS cause the mitochondria to swell and disrupt their internal folded membranes, known as cristae, which house the electron transport chain

Cephalalgia , 7, 46 48

In conclusion, on the basis of these studies, this review speculated that there may be two mechanisms of ferroptosis leading to obesity: (i) In the autonomic nervous system, vagus and parasympathetic nerves in some organs or tissues may be affected by ferroptosis and become dysfunctional, while the inflammatory factors released from adipocytes lead to excessive sympathetic activation and hypothalamic neuronal ferroptosis which promotes the development of obesity through a series of processes

This work was a massive team effort