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The peptide-resin freed from the lys and asp-protecting group was suspended in a suitable solvent such as DMF, dichloromethane (DCM) or 1-methyl-2-pyrrolidone (NMP), a suitable cyclic coupling agent such as 2- (1H-benzotriazole)

For instance, survodutide achieved the improvement of MASH without worsening of fibrosis in up to 62% of participants versus 14% with placebo, and significantly reduced liver fat content measured by MRI-PDFF in the phase 2 trial in patients with MASH [82], further reinforcing the therapeutic relevance of dual GLP-1/GCGR engagement in MASH

Every medication has side effects, but some are more serious than others